When is intrauterine transfusion indicated

Fetal blood sampling and platelet transfusion carry a significant risk of life-threatening haemorrhage suitable platelets should always be immediately available when fetal blood sampling is performed.

There is an increasing trend to use a non-invasive approach with maternal intravenous immunoglobulin and steroids and to avoid fetal transfusion where possible.

The transfusion volume is determined from the fetal and platelet concentrate platelet count and estimated feto-placental volume.

Platelets are transfused more slowly than IUT red cells because of a risk of fetal stroke. If HPA-compatible platelets are not available in a clinically relevant time frame, random donor neonatal platelets should be transfused and will produce a temporary platelet increment in most cases.

Spontaneous recovery of the platelet count usually occurs within 1 to 6 weeks as maternally derived antibody levels fall. Welcome Publication Information Figures: Tables Preface Contents 1: Transfusion ten commandments 2: Basics of blood groups and antibodies 3: Providing safe blood 4: Safe transfusion — right blood, right patient, right time and right place 5: Adverse effects of transfusion 6: Alternatives and adjuncts to blood transfusion 7: Effective transfusion in surgery and critical care 8: Effective transfusion in medical patients 9: EFFECTIVE transfusion in obstetric practice Effective transfusion in paediatric practice Therapeutic apheresis Management of patients who do not accept transfusion Appendices Abbreviations and Glossary.

Welcome Publication Information Figures: Tables: Tables Preface Contents 1: Transfusion ten commandments 2: Basics of blood groups and antibodies 3: Providing safe blood 4: Safe transfusion — right blood, right patient, right time and right place 5: Adverse effects of transfusion 6: Alternatives and adjuncts to blood transfusion 7: Effective transfusion in surgery and critical care 8: Effective transfusion in medical patients 9: EFFECTIVE transfusion in obstetric practice Effective transfusion in paediatric practice Download as PDF.

Revised 23 Jan Accepted 05 Feb Published 20 Feb Abstract Background. Introduction The incidence of fetal anemia secondary to Rhesus alloimmunization has decreased since the implementation of Rh immunoglobulin prophylaxis in Rh-negative women.

Table 1. Figure 1. References I. Lindenburg, I. Van Kamp, and D. Zimmermann, P. Durig, R. Carpenter Jr. Moise, R. Carpenter, B. Kirshon, R. Deter, J. Sala, and L. Scheier, E. Hernandez-Andrade, E. Fonseca, and K. Smith Jr. Warner, M. Bergmann, and M. Benirschke and S. View at: Google Scholar L. Raio, F. Ghezzi, E. Di Naro et al. Gordon, O. Eytan, A. Jaffa, and D. R—R, Burshtein, A.

Levy, G. Holcberg, A. Zlotnik, and E. Suess, L. Goals of intrauterine transfusion are to prevent or treat fetal heart failure hydrops , which can be caused by anemia, and to allow the pregnancy to continue so the baby can be more developed when it is born. There are two methods to perform fetal blood transfusions. Intrauterine transfusion is performed in the hospital, usually on an outpatient basis.

The mother is given antibiotics, local anesthesia and IV sedation, which also sedates the fetus. The fetus may be given additional medication to stop movement. The mother will probably not have to spend the night in the hospital, but the doctor may prescribe antibiotics and medication to prevent labor.